About 70 employees are based in the two-floor space in the former United Airlines building along the Chicago River at 77 West Wacker Dr. The company was formerly based in Decatur.
"As we continue to grow our company, this location allows us to more easily reach global markets, while keeping us in close contact with U.S. farmers, customers and operations," said CEO Patricia Woertz in a statement.
ADM's space in the building includes a culinary facility for the company to showcase its portfolio of food ingredients, the company said.
ADM announced its plans to make Chicago its new home in December, shortly after it was unable to secure the special tax incentives it sought from Illinois lawmakers.