Company Overview of Sage Therapeutics, Inc

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Steven M. Paul M.D.

Founder, Interim Chief Scientific Officer, Founding Advisor and Director, Sage Therapeutics, Inc

Age	Total Calculated Compensation	This person is connected to 14 Board Members in 14 different organizations across 13 different industries. See Board Relationships
61	--

Background

Dr. Steven M. Paul, Steve, M.D. is an Advisor of PureTech Ventures. Dr. Paul is the Founding Chief Executive Officer and Scientific Advisory Board Member at Tal Medical. He is a Venture Partner at Third Rock Ventures, LLC. Dr. Paul joined Third Rock Ventures on October 05, 2010 and is a Senior Advisor to it and participates in the ideation and development of potential new companies. As a Venture Partner, he plays a more significant role in the ideation and development ... of new companies, serving in key management roles. He serves as a Scientific Advisor at Excalibur Fund Managers Limited. He founded Sage Therapeutics, Inc. in 2011 and serves as its Interim Chief Scientific Officer and Founding Advisor. Dr. Paul was the Director of Helen & Robert Appel Institute for Alzheimer's Research at Weill Cornell Medical College, Inc. Prior to his appointment at Weill Cornell, Dr. Paul spent 17 years at Eli Lilly, during which time he held several key leadership roles. Previously, Dr. Paul was the Executive Vice President of Science and Technology at Eli Lilly & Co., from July 2003 to February 28, 2010. He was the President of Lilly Research Laboratories of Eli Lilly & Co. from May 16, 2003 to February 28, 2010 and Vice President since 1998. Dr. Paul joined Eli Lilly & Co. in 1993 as the Vice President of Central Nervous System Discovery and Decision Phase Medical Research group in it and was the Group Vice President of Therapeutic Area Discovery Research and Clinical Investigation from 1996 to 2003. He was also the Vice President of Neuroscience Discovery Research at the company, helping to expand Lilly's R&D efforts in oncology and biotechnology - resulting in a pipeline of approximately 70 new molecular entities. He was the Scientific Director of National Institute of Mental Health in Bethesda and as the Chief of its Clinical Neuroscience branch. He was the President in Psychiatry and an Instructor in the department of Psychiatry at University of Chicago’s Pritzker School of Medicine. Dr. Paul was a Medical Director in the Commissioned Corps of the United States Public Health Service. Dr. Paul has been an Independent Director of Sigma-Aldrich Corporation since November 2006 and ImClone Systems Corporation since November 21, 2008. He serves as a Member of Scientific Advisory Board of PsychoGenics, Inc. and a Board Member of SAGE Therapeutics. Dr. Paul has been a Director for Alnylam Pharmaceuticals Inc. since September 2010 and Seaside Therapeutics LLC since July 2010. He serves as a Director of DemeRx, Inc, the Lilly Foundation, the Foundation of the NIH, Butler University, and the Indianapolis Zoological Society. He is the Chairman of the Board of Directors of Karuna Pharmaceuticals Inc. He serves as a Member of the National Advisory Mental Health Council. He has been a Director of Constellation Pharmaceuticals, Inc., since February 1, 2011. He serves as a Member of Scientific Advisory Board at Cerecor, Inc. He serves as a Member of Science Board at the FDA. Dr. Paul serves as Member of Science Advisory Board of The Mind Research Network. Dr. Paul served as a Director of BioCrossroads. He served as a Trustee of The Mind Research Network. He is a member of the Scientific Advisory Board of the Allen Institute for Brain Sciences and the Institute on Aging at the University of Pennsylvania’s School of Medicine. He was a Member of the National Institute of General Medical Sciences Advisory Council and was appointed by the Secretary of the Department of Health and Human Services. He is a Grant Reviewer for several National Institute of Health committees. Dr. Paul is an elected Fellow of the American Association for the Advancement of Science and a Member of the Institute of Medicine at the National Academy of Sciences and serves on the IOM’s Board on Health Sciences Policy. Dr. Paul is on the Editorial Boards of numerous scientific journals. Dr. Paul has authored or co-authored more than 500 papers and invited book chapters. He holds eight patents on inventions made at Lilly and NIH. He was listed as one of the most highly cited Neuroscientists in the world from 1980 to 2000 by Institute of Scientific Information. Dr. Paul was awarded a research fellowship in the Pharmacology Research Associate Training Program of the National Institute of General Medical Science to work with Dr. Julius Axelrod. He completed an Internship in Neurology at Charity Hospital in New Orleans. Dr. Paul is Board certified by the American Board of Psychiatry and Neurology. He received a Doctor of Medicine and a M.Sc. in Anatomy and Neuroanatomy from Tulane University School of Medicine in 1975 and a B.A. in Biology and Psychology from Tulane University in 1972.

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