September 16, 2014 9:52 PM ET

Biotechnology

Company Overview of MORPHOTEK INC.

Company Overview

MORPHOTEK INC. develops a pipeline of preclinical and clinical stage monoclonal antibodies to treat cancer, inflammation, and infectious diseases. Its pipeline of products include Farletuzumab, an investigational monoclonal antibody that targets folate receptor alpha; Amatuximab, an monoclonal antibody that targets mesothelin; MORAb-004, an investigational monoclonal antibody that targets endosialin, MORAb-022, an investigational monoclonal antibody that targets a proinflammatory; and MORAb-066, an investigational monoclonal antibody that targets tissue factor. The company’s products are used to treat ovarian cancer, nonsmall cell lung cancer, melanoma, colorectal carcinoma, sarcoma, mesothe...

210 Welsh Pool Road

Exton, PA 19341

United States

Founded in 1999

Phone:

610-423-6100

Fax:

610-423-6199

Key Executives for MORPHOTEK INC.

Co-Founder and Executive Vice President
Co-Founder
Chief Finance Officer and Vice President of Project Management
Chief Business Officer
Age: 51
Compensation as of Fiscal Year 2014.

MORPHOTEK INC. Key Developments

Stealth Biologics Announces Research Collaboration with Morphotek

Stealth Biologics LLC has announced a research collaboration with Morphotek, Inc. Under terms of the agreement, Stealth Biologics will use its protein design and optimization algorithms to engineer deimmunized biologics for application in cancer therapy. Morphotek will retain the right to develop and commercialize all deimmunized therapeutics resulting from the collaboration.

Morphotek, Inc. Announces Enrollment in Phase I Solid Tumor Study

Morphotek, Inc. has opened enrollment in a Phase I clinical study with MORAb-004 in pediatric patients with relapsed/refractory solid tumors. The open-label Phase I study will assess the safety, tolerability and pharmacokinetics of MORAb-004 administered in weekly intravenous infusions in pediatric patients. MORAb-004 is an investigational monoclonal antibody that specifically binds to endosialin/tumor endothelial marker-1 (TEM-1). The target is found to be expressed on the cell surface of cells called pericytes that are part of the tumor blood vessel architecture, as well as on fibroblast cells that are part of the tumor stroma. Morphotek obtained exclusive worldwide rights to develop and commercialize this antibody from the Ludwig Institute for Cancer Research (LICR).

Morphotek, Inc. Announces the Initiation of a New MoRab-004 Phase I Study in Pediatric Patients with Relapsed/Refractory Solid Tumors

Morphotek, Inc. announced that the Children's Oncology Group (COG) has opened enrollment in a Phase 1 clinical study with MORAb-004 in pediatric patients with relapsed/refractory solid tumors. The open-label Phase 1 study will assess the safety, tolerability and pharmacokinetics of MORAb-004 administered in weekly intravenous infusions in pediatric patients. MORAb-004 is an investigational monoclonal antibody that specifically binds to endosialin/tumor endothelial marker-1 (TEM-1). The target is found to be expressed on the cell surface of cells called pericytes that are part of the tumor blood vessel architecture, as well as on fibroblast cells that are part of the tumor stroma. The company obtained exclusive worldwide rights to develop and commercialize this antibody from the Ludwig Institute for Cancer Research (LICR).

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