September 18, 2014 3:17 AM ET

Biotechnology

Company Overview of Diartis Pharmaceuticals, Inc.

Company Overview

Diartis Pharmaceuticals, Inc., a biopharmaceutical company, develops therapeutic proteins for the treatment of metabolic disorders. Its development portfolio includes VRS-859, a glucagon-like peptide-1 analog that provides improved therapeutic outcomes for Type 2 diabetic patients. The company was incorporated in 2010 and is based in Redwood City, California.

275 Shoreline Drive

Suite 450

Redwood City, CA 94065

United States

Founded in 2010

Phone:

650-963-8595

Key Executives for Diartis Pharmaceuticals, Inc.

Founder
Age: 49
Senior Vice President of Business Development
Age: 45
Clinical Advisor
Clinical Advisor
Clinical Advisor
Compensation as of Fiscal Year 2014.

Diartis Pharmaceuticals, Inc. Key Developments

Diartis Pharmaceuticals, Inc. Presents VRS-859 Positive Clinical Results for Type 2 Diabetes

Diartis Pharmaceuticals, Inc. is presenting positive data from its completed Phase 1 multicenter clinical trial of VRS-859 (exenatide-XTEN) at the European Association for the Study of Diabetes (EASD) 48th Annual Meeting which began on October 1 in Berlin-Charlottenburg. VRS-859, a long-acting glucagon-like peptide-1 (GLP-1) analog, is being developed as a once monthly treatment for patients with type 2 diabetes mellitus (T2DM). The Phase 1 multicenter, blinded, placebo-controlled, single-ascending dose study was designed to evaluate the safety and tolerability of VRS-859 as well as the ability to maintain glycemic control for one month in T2DM patients after a single dose. The Phase 1 results in T2DM patients demonstrate that all doses administered (up to 200 mg) were well tolerated and no unexpected adverse events were noted. Furthermore, the PK of VRS-859 in these patients was dose linear and comparable to the profile predicted from preclinical studies, validating the half-life extension capability of the XTEN technology and supporting a once monthly dosing regimen for VRS-859. These results support the company's plan to conduct a 6-month repeat dose study to determine a safe and efficacious subcutaneous dose of VRS-859 in patients with T2DM. About VRS-859 The compound has been designed to provide improved therapeutic outcomes for T2DM patients including robust and sustained improvements in HbA1c, improved tolerability, prolonged half-life (up to monthly dosing), as well as enhanced administration of a liquid formulation via a fine-gauge needle. It is hoped that upon successful development, VRS-859 may allow T2DM patients to safely manage their glucose with a therapy that is superior to current treatments for diabetes.

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