July 10, 2014 11:37 PM ET

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Company Overview of SciFluor Life Sciences, LLC

Company Overview

SciFluor Life Sciences, LLC provides a fluorine based technology for therapeutics to improve drug profiles and to better understand how drugs are working in the body. It offers fluorination methods and technologies that enable the rapid, efficient synthesis of novel 18F tracers for empowered PET imaging. The company also provides develops Fluoropeutics, a fluorine-enabled development candidate for targeting a range of therapeutic indications, including central nervous system disorders, infectious diseases, cardiovascular and metabolic diseases, and oncology. SciFluor Life Sciences, LLC was founded in 2011 and is based in Boston, Massachusetts.

33 Arch Street

Suite 3201

Boston, MA 02110

United States

Founded in 2011

Phone:

617-419-1822

Fax:

617-419-1813

Key Executives for SciFluor Life Sciences, LLC

Founder and Chief Scientific Advisor
Director of Chemistry and Founder
Vice President of Business Development
Vice President and General Manager of Imaging
Vice President of Research
Compensation as of Fiscal Year 2014.

SciFluor Life Sciences, LLC Key Developments

SciFluor Life Sciences, LLC Presents at BioPharm America 2013, Sep-18-2013 09:30 AM

SciFluor Life Sciences, LLC Presents at BioPharm America 2013, Sep-18-2013 09:30 AM. Venue: Westin Boston Waterfront Hotel, Boston, Massachusetts, United States. Speakers: Arthur Hiller, CEO.

SciFluor Life Sciences, LLC Presents New Preclinical Data for SF0034, a Novel Potassium Channel Opener for Treatment of Partial-Onset Seizure

SciFluor Life Sciences, LLC presented new preclinical data for SF0034, a novel potassium channel opener for the treatment of partial-onset seizure. Results show that SF0034 demonstrated a five-fold increase in potency, improved selectivity and a favorable pharmacological profile in a series of in vitro and in vivo preclinical models compared to ezogabine, a therapy currently approved in the U.S. and other global markets for the treatment of partial-onset seizure. SF0034 is one of the lead compounds in the expanding SciFluor portfolio of Fluoropeutics(TM). SciFluor scientists have discovered small-molecule new chemical entities (NCEs) by strategically introducing fluorine or fluorine groups into the molecular structure of known compounds directed toward precedented biological targets. SciFluor utilizes the incorporation of fluorine to create drugs with improved pharmacological profiles that provide important benefits over existing therapies. SF0034 was discovered by incorporating fluorine into ezogabine, an approved treatment for partial-onset seizure that must be administered three times a day. Data show that SF0034 is five times more potent with decreased QTc liabilities and a more balanced excretion pro le. In addition, SF0034 is less active at the potassium channel that causes urinary retention, potentially alleviating a key side effect of ezogabine.

SciFluor Life Sciences, LLC Appoints Ben C. Askew, Ph.D. as Vice President, Research

SciFluor Life Sciences, LLC announced that Ben C. Askew, Ph.D., has joined the company as vice president, research. In this newly created position, Dr. Askew will oversee the development and expansion of the company's pipeline of Fluoropeutics(TM) -- a proprietary portfolio of new chemical entities (NCEs) consisting of fluorinated versions of small molecule drugs with substantial human clinical or post-marketing experience. Dr. Askew joins the company with more than 20 years of experience in senior research positions in the biotechnology and pharmaceutical industries, where he specialized in building high functioning medicinal chemistry organizations, defining early IP and long-term R&D strategy, and leading NCE discovery programs. Most recently, Dr. Askew served as entrepreneur-in-residence for Third Rock Ventures.

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