September 16, 2014 11:38 PM ET


Company Overview of X-Chem, Inc.

Company Overview

X-Chem, Inc. operates as a subsidiary of Pharmaceutical Product Development Inc.

100 Beaver Street Suite 101

Waltham, MA 02453

United States





Key Executives for X-Chem, Inc.

X-Chem, Inc. does not have any Key Executives recorded.

X-Chem, Inc. Key Developments

X-Chem Enters into Multi-Target Collaboration with Pfizer Inc

X-Chem, Inc. announced a multi-target collaboration with Pfizer Inc. The collaboration is focused on the potential development of several programs for the treatment of inflammatory and orphan diseases. Under the terms of the agreement, X-Chem is applying its discovery engine, which leverages a high diversity, proprietary DNA-encoded small molecule library to seek the identification of novel leads for the Pfizer programs. Pfizer has an exclusive option to license any compounds generated in the course of the collaboration. The financial terms of the agreement were not disclosed.

X-Chem and PsyBrain Establish Partnership to Discover New Psychiatric Medicines

X-Chem, Inc. announced it has entered into an partnership with PsyBrain, Inc. to discover new drugs for treating psychiatric illnesses. Under the terms of the agreement, X-Chem will conduct drug discovery efforts to identify lead compounds for therapeutic targets provided by PsyBrain. X-Chem will receive research and development funding for each project. Each X-Chem program licensed by PsyBrain is eligible for pre-clinical, clinical and sales milestones. Financial details were not disclosed.

X-Chem, Inc. Enters Expanded Global Drug Discovery Collaboration with AstraZeneca

X-Chem, Inc. announced it has entered into an expanded global drug discovery collaboration with AstraZeneca across all of the pharmaceutical company's therapeutic areas and multiple target classes. The companies had entered into a previous collaboration in May of 2012. AstraZeneca recently elected to license three drug discovery programs resulting from that effort, directed at, respectively, an oncology protein-protein interaction (PPI) target, a respiratory/inflammation PPI target, and an antibacterial target. AstraZeneca has opted to extend the initial research collaboration from two to five years. X-Chem will conduct drug discovery on at least 10 therapeutic targets per year going forward. Under the terms of the new agreement, X-Chem will receive committed research and development funding for each project. Each X-Chem program licensed by AstraZeneca is eligible for pre-clinical, clinical and sales milestones in the aggregate amount of up to $26 million. In addition, X-Chem will receive significant royalties for each successfully commercialized drug that results from a licensed collaboration program.

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