Company Overview of MakuCell, Inc.
MakuCell, Inc. provides regenerative medicine biotechnology solutions. Its platform technology co-modulates effects of the Wnt-signaling pathway for use in skin, hair, and nail-care products. MakuCell, Inc. was incorporated in 2010 and is based in Scottsdale, Arizona.
17470 North Pacesetter Way
Scottsdale, AZ 85255
Founded in 2010
Key Executives for MakuCell, Inc.
Chief Executive Officer and President
Co-Founder and Board Chairman
Compensation as of Fiscal Year 2013.
MakuCell, Inc. Key Developments
MakuCell, Inc. Announces Scientific Findings for its Proprietary Technology, Asymmtate(TM)
Jul 17 12
MakuCell, Inc. announced key scientific findings for its proprietary technology, Asymmtate(TM). Asymmtate(TM) is a cosmetic ingredient that influences the gene co-activator choice used by -catenin to encourage skin stem cell differentiation. The study's results showed that application of a cream containing Asymmtate(TM) is associated with down-regulation of the gene expression of pro-opiomelanocortin and up-regulation of melanocortin receptor in human skin compared to the base cream. Aging, especially photo-aging, causes differences in the distribution and activity of melanocytes to mottled pigmentation, freckles and lentigines (liver spots). The study results suggest that using a cream with Asymmtate(TM) may reverse gene expression changes associated with aging skin and with lentigines. Makucell's Vice President and Chief Medical Officer, Mark V. Dahl, MD, will be presenting the poster at the Cosmetic Boot Camp in Colorado Springs, Colorado, which takes place July 19 through 21, 2012. Asymmtate(TM) is a new approach to cellular aging, optimizing signals in the Wnt (pronounced "wint") pathway to energize the skin's stem cells, encouraging youthful cell behavior. Optimal signaling stimulates the skin stem cells to begin the process to keratinocytes, fibroblasts and other dermal cells which produce collagen, elastic tissue and substances in the supporting skin matrix. The result is younger-looking skin which appears firmer and smoother. This essential regenerative process is the key differentiator in Makucell's Renewnt(TM) skin care products. Renewnt(TM) skin care products are available exclusively through dermatologists or by ordering directly from Makucell.
MakuCell, Inc. Unveils Renewnt
Jun 21 12
MakuCell, Inc. unveiled the Renewnt(TM) brand, a revolutionary science-driven product line. Renewnt's(TM) proprietary ingredient, Asymmtate(TM), is a new approach to cellular aging, optimizing signals in the Wnt pathway to energize the skin's stem cells, encouraging youthful cell behavior. The result is younger-looking skin which appears firmer and smoother. This molecular process is the key to proprietary technology developed at USC's Keck School of Medicine and transferred to Makucell's Renewnt(TM) skin care line. The body's signals govern skin stem cells, controlling the decision to remain dormant, divide or differentiate (become normal, active tissue cells). Signals flow in pathways and multiple paths converge into one -- the Wnt pathway. Makucell's proprietary molecule Asymmtate(TM) encourages optimal signaling in the Wnt pathway. Optimal signaling stimulates the skin stem cells to begin the process to keratinocytes, fibroblasts and other dermal cells which produce collagen, elastic tissue and substances in the supporting skin matrix. This essential regenerative process is the key differentiator in Makucell's Renewnt(TM) skin care products. The products: Penetrate into viable skin. Are not irritating or sensitizing. Show measurable up-regulation of genes that express skin structural proteins with simultaneous down-regulation of inflammatory genes in gene expression analysis. Perform well in clinical studies. Skin shows smoothing, plumping and an improvement in texture after as little as four weeks. Renewnt(TM) for Hydration, a day and night facial moisturizer for a more youthful-looking appearance. Renewnt(TM) for Strength, for the dry, thinning skin on hands and forearms to seal in moisture, repair the signs of aging and restore the essential skin barrier. Renewnt(TM) for Firmness, a neck and decolletage cream hydrates and improves elasticity, reduces wrinkles and roughness, and visibly increases firmness. Renewnt(TM) for Brightness, a serum to address irregular skin pigmentation and sun damage to lighten and even skin color. Initially, Makucell is offering the Renewnt(TM) products exclusively through aesthetic skincare professionals and directly from Makucell by calling the toll free number 855-MAKUCELL. Makucell has a full portfolio of products in its pipeline directed toward improving the appearance of skin, hair and nails which use the Asymmtate(TM) core technology.
MakuCell, Inc. Appoints Kevin J. Scanlon to Board of Advisors
May 21 12
MakuCell, Inc. announced the appointment of Kevin J. Scanlon, Ph.D., to its Board of Advisors. Dr. Scanlon's multifaceted career includes three start-up companies, pharmaceutical industry senior management and academic medicine.
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