July 22, 2014 1:44 PM ET

Company Overview of J. David Gladstone Institutes

Company Overview

1650 Owens Street

San Francisco, CA 94158-2261

United States

Founded in 1971





Key Executives for J. David Gladstone Institutes

J. David Gladstone Institutes does not have any Key Executives recorded.

J. David Gladstone Institutes Key Developments

ALS Therapy Development Institute and J. David Gladstone Institutes Collaborate to Discover Potential ALS Treatments

ALS Therapy Development Institute and J. David Gladstone Institutes announced the formation of a research collaboration to speed the discovery of potential treatments for ALS through the preclinical drug development process. Under this new agreement, which starts immediately, Gladstone will evaluate potential pharmaceutical compounds using a human model of ALS. Gladstone generated the model by transforming skin cells from ALS patients into stem cells, known as induced pluripotent stem cells (iPS cells), and then programming them into neurons. The technique builds on a discovery for which Shinya Yamanaka, MD, PhD, a Gladstone senior investigator, won the 2012 Nobel Prize in Physiology or Medicine. This particular iPS-based ALS model includes a gene mutation that produces TDP-43, a protein commonly found in most forms of ALS. Promising drug compounds that pass the initial evaluation process at Gladstone will be fast-tracked for pre-clinical testing at ALS TDI, which will assess the compounds for activity and efficacy in various mouse models of human neurodegeneration.

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