Cellexus Limited researches, develops, and provides single-use bioreactors and cell-based technologies for biopharmaceutical research, production, and contract manufacturing applications. The company offers CellMaker PLUS, a single-use and disposable bioreactor cell culture control instrument used for the growth of various cell types, including E. coli, pichia, algae, and bacteriophage, as well as mammalian and insect cells; Cellexus Oxygenator, an oxygen generator module; and CellexusBag, a cell culture bioreactor bag that is used to set-up and optimize cell culture and fermentation processes. It also offers bioreactor consumables, applications, data, and technical support and services. The...
15 Hostmoor Avenue
March, PE15 0AX
Founded in 2005
Cellexus Limited Announces Launch of the New CellMaker PLUS
Dec 9 13
Cellexus Limited announced the launch of the new CellMaker PLUS. This highly flexible, robust and easy-to-use single-use bioreactor system comes with improved control software and comes complete with full pH and dissolved oxygen (DO) control. The system is designed for microbial applications, especially bacterial and yeast cell culture, providing the ODs and improved yields of soluble protein in oxygen hungry cell types such as E.coli. Production, QC and service of the fully CE marked system is conducted from the new Cellexus facilities in Cambridgeshire (UK) which is ISO9001 certified. The new CellMaker PLUS has been proven to provide highly efficient oxygen transfer allowing high rates of cell growth outperforming bacterial and yeast cell culture in other systems. It uses CellMaker PLUS Bags which are unique, next generation single-use, disposable cell culture bags in which the cells are grown with fast set-up times, no cleaning requirements and no cross-contamination. The CellMaker PLUS Bags also come with integrated, disposable pH and DO sensors to enable pH and DO to be closely monitored and controlled in the CellMaker PLUS system. Whilst other disposable systems require shakers, rockers, rollers or large environmental chambers, the CellMaker PLUS employs a novel airlift technology, available only from Cellexus, to mix and efficiently aerate the cells, which is simple, scalable and inexpensive to use. When the CellMaker PLUS Bag is placed in the system it is very efficiently aerated, with controlled air and oxygen flow for optimal cell growth and gentle, effective mixing to maintain cells in suspension. Oxygen levels are carefully monitored and controlled to ensure oxygen levels are maintained during growth of oxygen hungry cells such as E.coli. Temperature control enables production of the high yields of soluble protein under optimal conditions. The CellMaker PLUS also monitors and controls pH levels with automatic addition of acid and base when required to ensure pH is maintained at the optimal level for best cell growth. System controls are displayed on a touch screen on which users can quickly and conveniently amend user definable functions. Process conditions are displayed in real time and data stored on the on board computer and presented as a CSV file for easy manipulation in a spreadsheet format. This new, improved control system incorporates many features identified by users, for example the calibration routines are simpler and semi-automated. There is also capability to set maximum/minimum gas levels and the volumes of acid and base dosed into the system are displayed so the control system can be adapted to suit most applications.