August 22, 2014 8:12 AM ET

Pharmaceuticals

Company Overview of Adheron Therapeutics, Inc.

Company Overview

Adheron Therapeutics, Inc. develops pharmaceuticals for the treatment of rheumatoid arthritis and fibrotic diseases. Its product SDP051, is a Cad-11 antagonist that acts as an adhesive between cells and changes in these Cad-11 interactions can induce the cells to produce many proteins that influence the cellular environment positively or adversely. The company's product is used in pulmonary fibrosis and skin fibrosis. Adheron Therapeutics, Inc. was formerly known as Synovex Corporation. The company was incorporated in 2003 and is based in Berkeley, Massachusetts.

2930 Domingo Avenue

Mail Boxes Plus

Mail Box 104

Berkeley, MA 94705

United States

Founded in 2003

Key Executives for Adheron Therapeutics, Inc.

Scientific Founder
Scientific Founder
Co-Founder and Director
Age: 74
Chief Scientific Officer
Compensation as of Fiscal Year 2014.

Adheron Therapeutics, Inc. Key Developments

Adheron Therapeutics Announces Favorable Phase 1 Clinical Trial Results

Adheron Therapeutics announced the completion of the company's Phase 1 clinical trial for its leading Cad-11 inhibitor SDP051. Cad-11 acts as a key mediator of joint destruction in rheumatoid arthritis, and is also an important contributor to fibrotic pathology. These are disease pathways that Adheron Therapeutics is particularly interested in pursuing. SDP051 is a humanized monoclonal antibody to Cadherin-11, which acts as an adhesive between cells. Changes in Cad-11 interactions can induce cells to produce proteins that influence the cellular environment. The recently completed SDP051 trial was designed to assess the safety and tolerability of an escalating single dose of the compound in healthy volunteers who received SDP051 or placebo. The trial also assessed the pharmacokinetic properties of the protein in vivo. Results from the Phase 1 trial show that SDP051 is safe and well-tolerated at doses up to 10 mg/kg per day with no evidence of significant side effects.

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