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acucela inc (4589) Details

Acucela Inc. discovers and develops therapeutic products to treat and slow the progression of sight-threatening ophthalmic diseases worldwide. It focuses on developing oral products based on its proprietary visual cycle modulation (VCM) compounds to address various retinal diseases, primarily age-related macular degeneration, diabetic retinopathy, and diabetic macular edema, as well as potentially Stargardt disease, retinitis pigmentosa, and retinopathy of prematurity. The company’s product candidates include Emixustat hydrochloride, which is in Phase IIb/III clinical trial for the treatment of age-related macular degeneration; and OPA-6566, an adenosine A2a receptor agonist that is in Phase I/II clinical trial to treat ocular hypertension and open-angle glaucoma as a topical ophthalmic solution. It has a co-development and collaboration agreement with Otsuka Pharmaceutical Co., Ltd. for Emixustat and OPA-6566. Acucela Inc. was founded in 2002 and is based in Seattle, Washington.

84 Employees
Last Reported Date: 03/28/14
Founded in 2002

acucela inc (4589) Top Compensated Officers

Founder, Chairman and Chief Executive Officer
Total Annual Compensation: $521.9K
Vice President of Human Resources
Total Annual Compensation: $259.5K
Compensation as of Fiscal Year 2013.

acucela inc (4589) Key Developments

Acucela Inc. Announces Board Appointments

Acucela Inc. announced that Brian O’Callaghan, the company’s President and Chief Operating Officer, will assume the role of Chief Executive Officer, along with continuing to serve as Interim Chief Financial Officer. Ryo Kubota, M.D., Ph.D., the company’s Founder, will retain his position as Chairman of the company’s Board of Directors. Mr. O’Callaghan will assume the role of CEO effective January 1, 2015.

Acucela Inc. Revises Earnings Guidance for the Year Ending December 31, 2014

Acucela Inc. revised earnings guidance for the year ending December 31, 2014. For the year, the company now expects revenue from collaborations to be $34,739,000 against previously expected of $61,840,000. Operating income to be $693,000 against previously expected of $836,000. Income before income tax to be $250,000 against previously expected of $433,000. Net loss to be $1,997,000 or $0.06 per share against previously expected net income of $264,000 or $0.02 per share.

Acucela Inc. Announces Results on the Pharmacodynamic Properties of Emixustat Hydrochloride in Patients

Acucela Inc. announced that results on the pharmacodynamic properties of emixustat hydrochloride in patients with geographic atrophy will be presented by Roger L. Novack, MD, PhD, Retina-Vitreous Associates Medical Group, Beverly Hills, California, during a podium session at the American Academy of Ophthalmology (AAO) 2014 Annual Meeting in Chicago, IL on October 21, 2014 at 10:46AM, CT. Emixustat, the first internally developed investigational compound by Acucela, is orally dosed, targets the visual cycle, and is in development for the treatment of GA associated with dry AMD. Dr. Novack was one of the investigators in Acucela's Phase 2a clinical study and is currently participating as an investigator in the Phase 2b/3 "SEATTLE" study.


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