Last $7.09 USD
Change Today +0.28 / 4.11%
Volume 3.4M
ARIA On Other Exchanges
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As of 8:10 PM 12/26/14 All times are local (Market data is delayed by at least 15 minutes).

ariad pharmaceuticals inc (ARIA) Snapshot

Open
$6.86
Previous Close
$6.81
Day High
$7.09
Day Low
$6.85
52 Week High
01/24/14 - $9.83
52 Week Low
10/13/14 - $4.90
Market Cap
1.3B
Average Volume 10 Days
6.3M
EPS TTM
$-1.22
Shares Outstanding
187.2M
EX-Date
--
P/E TM
--
Dividend
--
Dividend Yield
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Current Stock Chart for ARIAD PHARMACEUTICALS INC (ARIA)

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ariad pharmaceuticals inc (ARIA) Details

ARIAD Pharmaceuticals, Inc., an oncology company, is engaged in the discovery, development, and commercialization of medicines for cancer patients. It offers Iclusig (ponatinib), a tyrosine kinase inhibitor for the treatment of adult patients with chronic myeloid leukemia (CML), and Philadelphia chromosome-positive acute lymphoblastic leukemia in the United States and Europe. The company is also developing Iclusig for other blood cancers and solid tumors, such as gastrointestinal stromal tumors, acute myeloid leukemia, and certain forms of non-small cell lung cancer; and various investigator-sponsored trials in indications, including first line and second line CML, acute myeloid leukemia, non-small cell lung cancer, and medullary thyroid cancer. In addition, its product pipeline consists of AP26113, an investigational inhibitor of anaplastic lymphoma kinase for treating advanced solid tumors comprising non-small cell lung cancer; and Ridaforolimus, an investigational mTOR inhibitor for various types of cancers. The company sells and markets Iclusig through specialty pharmacies and specialty distributors in the United States. It has collaboration and license agreement with Merck & Co., Inc. for the development, manufacture, and commercialization of ridaforolimus for use in cancer; and license agreements with Medinol Ltd. and ICON Medical Corp. to develop and commercialize stents and other medical devices to deliver ridaforolimus. ARIAD Pharmaceuticals, Inc. was founded in 1991 and is headquartered in Cambridge, Massachusetts.

307 Employees
Last Reported Date: 03/3/14
Founded in 1991

ariad pharmaceuticals inc (ARIA) Top Compensated Officers

Principal Founder, Chairman, Chief Executive ...
Total Annual Compensation: $749.8K
Chief Financial Officer, Executive Vice Presi...
Total Annual Compensation: $465.4K
President of Research & Development and Chief...
Total Annual Compensation: $492.4K
Chief Medical Officer and Senior Vice Preside...
Total Annual Compensation: $679.0K
Chief Commercial Officer and Executive Vice P...
Total Annual Compensation: $427.3K
Compensation as of Fiscal Year 2013.

ariad pharmaceuticals inc (ARIA) Key Developments

ARIAD Pharmaceuticals, Inc. and Otsuka Pharmaceutical Co., Ltd. Announce Co-Development and Commercialization Agreement for Iclusig to Treat Leukemias in Japan and Nine Other Asian Countries

ARIAD Pharmaceuticals Inc. and Otsuka Pharmaceutical Co., Ltd. announced that they have entered into an agreement for Otsuka to commercialize ARIAD’s Iclusig (ponatinib) in Japan and nine other Asian countries and to fund future clinical trials in those countries. ARIAD will lead the completion of the Japanese New Drug Application (NDA) for Iclusig, and Otsuka will file the NDA on behalf of both companies for regulatory approval in resistant and intolerant chronic myeloid leukemia (CML) and Philadelphia-chromosome positive acute lymphoblastic leukemia (Ph+ALL) in 2015. Iclusig is an approved BCR-ABL inhibitor in the United States, Europe and Australia. The agreement provides for Otsuka to receive exclusive rights to market Iclusig in Japan and nine other Asian countries (Territory) in return for an upfront payment of $77.5 million to ARIAD, a milestone payment upon regulatory approval in Japan for patients with resistant and intolerant Philadelphia-positive leukemias, and additional milestone payments for approval in other indications. Following approvals in the Territory, Otsuka will conduct sales activities and record sales. ARIAD will also receive a substantial share of net product sales.

Ariad Pharmaceuticals Inc. Announces Long-Term Safety and Efficacy Data of Ponatinib from Phase 2 Pace Clinical Trial

ARIAD Pharmaceuticals Inc. announced long-term follow up from its pivotal Phase 2 trial of Iclusig (ponatinib), its approved BCR-ABL inhibitor, in heavily pretreated patients with resistant or intolerant chronic myeloid leukemia (CML) or Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL). The study now shows that with a median follow-up of approximately 3 years for chronic-phase CML (CP-CML) patients in the trial, Iclusig continues to demonstrate anti-leukemic activity in patients with limited treatment options. Deep and durable responses have been maintained in CP-CML patients with 83 percent of CP-CML patients who achieved a response, estimated to remain in major cytogenetic response (MCyR) at three years. Additionally, the rate of maintenance of response in CP-CML patients was high (greater than 90%) in patients who underwent Iclusig dose reductions. Long-term safety data confirm that careful benefit-risk evaluations should guide the decision to use and then maintain Iclusig therapy, particularly in patients who may be at increased risk for arterial thrombotic events. PACE Trial Update: The efficacy and safety of ponatinib in CML and Ph+ ALL patients resistant or intolerant to dasatinib or nilotinib, or with the T315I mutation, were evaluated in the pivotal Phase 2 PACE trial. A total of 449 patients were treated with ponatinib at a starting dose of 45 mg/day Ninety-three percent of patients treated in the PACE trial had failed two or more prior tyrosine kinase inhibitors (TKI), and 58 percent had failed three or more prior TKIs. Updated data in CP-CML patients (n=270) from the ongoing trial indicate that with a median follow-up of 38.4 months (data as of October 6, 2014), 121 patients (45%) continue to receive ponatinib. Additional data in CP-CML patients include: 55% of CP patients met the primary endpoint of MCyR by 12 months; 83% of patients who responded are estimated to remain in MCyR at 3 years; 39% of patients achieved a major molecular response (MMR) or better; By Kaplan-Meier analysis, progression-free survival at 3 years is estimated to be 61%; Overall survival at 3 years is estimated to be 82%; 22% of CP patients experienced an arterial thrombotic serious adverse event (SAE), and 27 percent of CP-CML patients experienced any arterial thrombotic event, independent of severity or attribution of relationship to ponatinib. There was no increase in the exposure-adjusted incidence of newly occurring arterial thrombotic events with longer follow-up; 4% of CP patients experienced a venous thrombotic SAE; The most common all-grade treatment-emergent adverse events in CP-CML were rash (46%), thrombocytopenia (45%), abdominal pain (45%), headache (43%), constipation (41%) and dry skin (41%); the discontinuation rate for adverse events was 17% in CP-CML.

Shire And AstraZeneca Mulls Acquisition Of Ariad

Shire plc (LSE:SHP) and AstraZeneca PLC (LSE:AZN) are rumored to acquire Ariad Pharmaceuticals Inc. (NasdaqGS:ARIA). Shire and AstraZeneca are stalking Ariad and an auction could ensue. Shares of Ariad closed at $7.38, Astra Zeneca at £46.74 and Shire at £45.63.

 

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Valuation ARIA Industry Range
Price/Earnings NM Not Meaningful
Price/Sales 28.3x
Price/Book 16.4x
Price/Cash Flow NM Not Meaningful
TEV/Sales 19.2x
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