Last $33.29 USD
Change Today +0.08 / 0.24%
Volume 100.9K
EPZM On Other Exchanges
As of 1:43 PM 07/24/14 All times are local (Market data is delayed by at least 15 minutes).

epizyme inc (EPZM) Snapshot

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10/1/13 - $42.71
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epizyme inc (EPZM) Details

Epizyme, Inc., a clinical stage biopharmaceutical company, discovers and develops personalized therapeutics for patients with genetically defined cancers. It identifies the genetic alterations that create cancer causing genes, known as oncogenes; selects patients in whom the identified genetic alteration is found; and designs small molecule therapeutic product candidates to inhibit the oncogene. The company has two histone methyltransferases (HMT) inhibitors in clinical development for the treatment of patients with genetically defined cancers. It is conducting a Phase I clinical trial of its product candidate, EPZ-5676, an inhibitor targeting the DOT1L HMT for the treatment of acute leukemias with genetic alterations of the MLL gene; and a Phase I/II clinical trial of another product candidate, EPZ-6438, an inhibitor targeting the EZH2 HMT for the treatment of a genetically defined subtype of non-Hodgkin lymphoma and solid tumors, including INI1-deficient tumors, such as synovial sarcoma and malignant rhabdoid tumors. The company has therapeutic collaborations with Celgene Corporation and Celgene International Sàrl; Eisai Co., Ltd.; and Glaxo Group Limited., as well as companion diagnostic collaborations with Roche Molecular Systems, Inc. and Abbott Molecular Inc. Epizyme, Inc. was founded in 2007 and is headquartered in Cambridge, Massachusetts.

74 Employees
Last Reported Date: 02/28/14
Founded in 2007

epizyme inc (EPZM) Top Compensated Officers

Chief Executive Officer, Secretary and Direct...
Total Annual Compensation: $564.7K
President, Chief Financial Officer, Principal...
Total Annual Compensation: $513.2K
Chief Scientific Officer and Executive Vice P...
Total Annual Compensation: $487.5K
Chief Medical Officer
Total Annual Compensation: $463.5K
Compensation as of Fiscal Year 2013.

epizyme inc (EPZM) Key Developments

Epizyme Mulls Acquisitions

Epizyme, Inc. (NasdaqGS:EPZM), which has filed for a shelf registration in the amount of $200 million, is looking for acquisitions. The company stated, “We intend to use the net proceeds from the sale of any securities offered under this prospectus for general corporate purposes unless otherwise indicated in the applicable prospectus supplement. General corporate purposes may include the acquisition of companies or businesses, repayment and refinancing of debt, if any, working capital and capital expenditures.”

Epizyme, Inc. Announces Board Changes

Epizyme, Inc. in its AGM held on June 9, 2014, elected Andrew R. Allen, M.D., Ph.D. as a class I director, for a three-year term ending at the annual meeting of stockholders to be held in 2017. Thomas O. Daniel, M.D. and Kazumi Shiosaki, Ph.D. did not stand for re-election at the Annual Meeting of Stockholders. Dr. Shiosaki delivered a written resignation to the company on June 9, 2014 confirming that she no longer serves as a director.

Epizyme, Inc. Announces Presentation on Pre-Clinical Models and Early Clinical Observations of EZH2 Inhibitor EPZ-6438

Epizyme, Inc. announced that an abstract on EPZ-6438 has been accepted for oral presentation at the American Society of Hematology (ASH) Meeting on Lymphoma Biology, to be held August 10-13 in Colorado Springs, Colorado. The presentation will include findings characterizing the activity of EPZ-6438, a small molecule inhibitor of EZH2, in pre-clinical models of non-Hodgkin lymphoma (NHL), both as a single agent and in combination with NHL standards of care. The presentation will also highlight the early clinical experience from an ongoing Phase 1 study of EPZ-6438 (E7438) in patients with advanced malignancies, including NHL. Activity of the EZH2 inhibitor EPZ-6438 (E7438) in Non-Hodgkin Lymphoma: Pre-clinical Models and Early Clinical Observations.


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