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genomic health inc (GHDX) Details

Genomic Health, Inc., a healthcare company, provides actionable genomic information to personalize cancer treatment decisions in the United States and internationally. It develops and commercializes genomic-based clinical laboratory services that analyze the underlying biology of cancer, facilitating physicians and patients to make individualized treatment decisions. The company offers the Oncotype DX invasive breast cancer test that is used for early stage invasive breast cancer patients to predict the likelihood of breast cancer recurrence and the likelihood of chemotherapy benefit. It also provides the Oncotype DX colon cancer test, which is used to predict the likelihood of colon cancer recurrence in patients with stage II disease, as well as for use in patients with stage III disease treated with oxaliplatin-containing adjuvant therapy. In addition, the company provides the Oncotype DX tests for patients with ductal carcinoma in situ, a pre-invasive form of breast cancer; and Oncotype DX prostate cancer test, which provides a genomic prostate score to predict disease aggressiveness in men with low risk disease, as well as is used to enhance treatment decisions for prostate cancer patients in conjunction with the Gleason score or tumor grading. Genomic Health, Inc. was founded in 2000 and is based in Redwood City, California.

684 Employees
Last Reported Date: 03/11/14
Founded in 2000

genomic health inc (GHDX) Top Compensated Officers

Chairman of the Board, Chief Executive Office...
Total Annual Compensation: $600.0K
Chief Financial Officer, Chief Operating Offi...
Total Annual Compensation: $469.2K
Executive Vice President of Research & Develo...
Total Annual Compensation: $459.2K
Total Annual Compensation: $353.8K
Compensation as of Fiscal Year 2013.

genomic health inc (GHDX) Key Developments

Genomic Health, Inc. Announces Management Changes

On June 13, 2014, Dean L. Schorno, Chief Financial Officer of Genomic Health Inc. notified the company that he would be resigning from his position to pursue a chief financial officer opportunity with a privately held company. Mr. Schorno will remain available for consultation during a transition period. The company's Board of Directors has appointed G. Bradley Cole, the company's Chief Operating Officer, to serve in the additional positions of Chief Financial Officer and principal financial and accounting officer effective June 19, 2014. Mr. Cole, age 58, has served as the company's Chief Operating Officer since January 2009, and also served as the company's Chief Financial Officer from July 2004 until January 2011. The company intends to conduct a search for a new Chief Financial Officer.

Genomic Health Announces Positive Topline Results of Second Large, Independent Validation Study of Oncotype DX(R) in DCIS Breast Cancer

Genomic Health Inc. announced positive preliminary results from a second large, independent clinical validation study of Oncotype DX(R) in patients with a pre-invasive form of breast cancer, also known as DCIS (ductal carcinoma in situ). The study, conducted by the Ontario DCIS Study Group in Canada, met its primary endpoint by demonstrating that the Oncotype DX DCIS Score(TM) predicts the risk of local recurrence, defined as either the development of a new invasive breast cancer or the recurrence of DCIS in the same breast. Representing the genomic study in DCIS to date, these results confirm and extend the conclusions of the previously published validation study performed by the ECOG-ACRIN Cancer Research Group. Additionally, for the first time, the Oncotype DX DCIS Score predicted the risk of local recurrence in a group of patients treated with radiation therapy in clinical practice. Genomic Health and the Ontario DCIS Study Group are submitting the results from this study for presentation at the 2014 San Antonio Breast Cancer Symposium in December. Genomic Health researchers collaborated with the Ontario DCIS Study Group to examine a population-based cohort of more than 1,200 DCIS patient tumor samples collected from patients diagnosed with DCIS between 1994 and 2003, including both patients treated with surgery alone and patients treated with surgery plus radiation. DCIS -- an early, non-invasive form of breast cancer, considered stage zero, in which the tumor cells are confined within the milk ducts in the breast -- affects one out of every five women diagnosed with breast cancer in the U.S. Most women with DCIS who receive breast-conserving surgery without standard radiotherapy will not develop a local recurrence. However, an estimated 80% of these women currently receive additional treatments that may not be necessary, while other women may not appropriately receive more aggressive treatment resulting in the development of cancers that might have been preventable with treatment. To help a woman and her doctor make a more informed decision about her DCIS treatment, Genomic Health developed the Oncotype DX DCIS Score to provide more precise information about her individual risk of a recurrence of either DCIS or invasive breast cancer by looking at 12 genes within a tumor sample to reveal the aggressiveness of the disease. A clinical decision impact study recently presented at ASCO(R) demonstrated that the Oncotype DX DCIS Score results changed treatment recommendations for one out of three patients with DCIS, highlighting the need for optimizing treatment of this non-invasive form of breast disease.

Genomic Health Demonstrates the Importance of Utilizing Multiple Biological Pathways to Predict Tumor Behavior in Prostate and Renal Cancers

Genomic Health Inc. announced results of two studies demonstrating the ability of its Oncotype DX(R) test and a new 16-gene panel to predict disease aggressiveness and clinical outcomes in prostate and renal cancers, respectively. These results, presented at the American Society of Clinical Oncology(R) (ASCO(R)) Annual Meeting in Chicago, underscore the company's successful approach to understanding tumor biology, resulting in tests that incorporate distinct genes across multiple pathways to provide more precise risk assessment than currently available risk factors and help improve treatment decision making. In the prostate cancer study, researchers at the University of California, San Francisco (UCSF) conducted an analysis of 395 patient samples to evaluate the ability of the Oncotype DX Genomic Prostate Score (GPS) to predict cancer aggressiveness despite variability in pathology assessment. The analysis revealed that original pathology readings of tumor grade and stage, rendered by more than 15 pathologists, frequently differed from the central review that was performed by a single expert urologic pathologist as part of the clinical validation study. For both biopsy and radical prostatectomy specimen evaluation, the pathology results for Gleason Score were different in one out of every four patients (24% and 26%, respectively). Despite these discordances, GPS remained a robust predictor of adverse pathology at surgery.


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