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ico therapeutics inc (ICO) Details

iCo Therapeutics Inc., a biotechnology company, focuses on the identification, development, and commercialization of drug candidates to treat sight and life threatening diseases. Its in-licensed product candidates include iCo-007, an antisense inhibitor that is in Phase II clinical trial for the treatment of diabetic macular edema; and iCo-008 (Bertilimumab), a human immunoglobulin monoclonal antibody, which is in Phase I clinical trial to treat sight threatening ocular allergies and various systemic indications. The company also develops Oral Amphotericin B Delivery System that is in pre-clinical stage used for the treatment of systemic fungal infections in immune-compromised patients, such as in HIV/AIDS, cancer, transplant recipients, diabetics, etc., as well as certain parasitical infections. iCo Therapeutics Inc. has partnership arrangements with Isis Pharmaceuticals, Inc.; MedImmune Limited; Immune Pharmaceuticals Inc.; AstraZeneca; and the University of British Columbia. iCo Therapeutics Inc. was founded in 2005 and is headquartered in Vancouver, Canada.

5 Employees
Last Reported Date: 04/24/14
Founded in 2005

ico therapeutics inc (ICO) Top Compensated Officers

Co-Founder, Chief Executive Officer, Presiden...
Total Annual Compensation: C$234.7K
Chief Financial Officer and Corporate Secreta...
Total Annual Compensation: C$140.0K
Chief Medical Officer
Total Annual Compensation: C$160.0K
Compensation as of Fiscal Year 2013.

ico therapeutics inc (ICO) Key Developments

iCo Therapeutics Inc. Announces Advancement of Oral Amphotericin B Program

iCo Therapeutics Inc. announced next steps for its Oral Amphotericin B program. The company recently announced positive findings from its in vitro work involving samples from HIV/AIDS patients exposed to HAART therapy. iCo now plans to complete pre clinical studies and regulatory filings to move forward with an initial Phase 1A clinical trial, utilizing approximately $700,000 of funding and technological advice from the National Research Council of Canada Industrial Research Assistance Program (NRC-IRAP), under the Canadian HIV Technology Development (CHTD) Program. The preparation and regulatory filings are expected to be completed in the second half of 2015, with initiation of a Phase 1A study early in the first quarter of 2016. iCo has also been building its intellectual property position around the Oral Amphotericin B asset. The company was issued composition of matter and use patents, titled: Formulations for Oral Administration of Therapeutic Agents and Related Methods, issued in the United States, Russia, Singapore, New Zealand and notice of allowance in China. Management is aggressively pursuing further patent issuances in multiple jurisdictions as it moves towards the clinic. Current Amphotericin B product, AmBisome, marketed by Gilead, had sales of $352 million in 2013, but it is severely limited in its application because of its toxicity and IV delivery. An oral delivery platform would open up the market for the treatment of infections and outpatient treatment regimes, as well as developing world treatments where IV is not practical.

iCo Therapeutics Inc. Announces Earnings Results for the Six Months Ended June 30, 2014

iCo Therapeutics Inc. announced earnings results for the six months ended June 30, 2014. The company incurred total comprehensive loss of CAD 1,617,040 or loss per share of CAD 0.02 for the six months ended June 30, 2014 compared to a total comprehensive loss of CAD 2,886,831 or loss per share of CAD 0.05 for the six months ended June 30, 2013, representing a decrease of CAD 1,269,791 in comprehensive loss. The decrease in net comprehensive loss is primarily a result of a CAD 259,755 increase in the carrying value of its investment in Immune Pharmaceuticals, as well as a decrease in expenses associated with the iDEAL trial.

iCo Therapeutics Inc. Announces Positive Oral Amphotericin B Study Results

iCo Therapeutics Inc. reported results of its Oral Amphotericin B (Oral Amp B) drug candidate targeting latent HIV reservoirs. The study, conducted by ImmuneCarta(R), the immune monitoring business unit of Caprion, evaluated in vitro effectiveness of Oral Amp B in reactivating latent HIV viral reservoirs which remain present in individuals despite intensive treatment with antiretroviral therapy. Memory cells, or white blood cells, from eight HIV-infected subjects with a durable viral suppression using antiretroviral therapy (HAART) were obtained and exposed in vitro to various concentrations of Oral Amp B. Samples from one patient were determined not to be susceptible to reactivation. In the remaining subjects, Oral Amp B demonstrated a reactivation response of HIV viral production in six out of seven in vitro cultures with detectable HIV reservoir. Some HIV reservoirs are not possible to reactivate and this may explain why one culture did not show reactivation response.


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