Last $39.58 USD
Change Today -0.43 / -1.07%
Volume 3.2M
As of 5:20 PM 08/27/14 All times are local (Market data is delayed by at least 15 minutes).

isis pharmaceuticals inc (ISIS) Snapshot

Open
$40.20
Previous Close
$40.01
Day High
$41.44
Day Low
$39.33
52 Week High
02/24/14 - $62.66
52 Week Low
05/9/14 - $22.25
Market Cap
4.7B
Average Volume 10 Days
1.8M
EPS TTM
$-0.80
Shares Outstanding
117.7M
EX-Date
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P/E TM
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Dividend
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Dividend Yield
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Current Stock Chart for ISIS PHARMACEUTICALS INC (ISIS)

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isis pharmaceuticals inc (ISIS) Details

Isis Pharmaceuticals, Inc. is engaged in the discovery and development of antisense drugs using novel drug discovery platform. The company’s flagship product includes the KYNAMRO injection, which is an apo-B synthesis inhibitor for patients with homozygous familial hypercholesterolemia; and for the reduction of low-density lipoprotein cholesterol. It also has a pipeline of 31 drugs in development for the treatment of various diseases, including cardiovascular and metabolic diseases; severe and rare diseases, including neurological disorders; and cancer. The company has strategic alliances and collaboration agreements primarily with AstraZeneca AB, Biogen Idec MA Inc., Bristol-Myers Squibb, Eli Lilly and Company, Genzyme Corporation, GlaxoSmithKline, Hoffman-La Roche Inc., F. Hoffmann-La Roche Ltd., Alnylam Pharmaceuticals, Inc., Antisense Therapeutics Limited, Excaliard Pharmaceuticals, Inc., iCo Therapeutics Inc., OncoGenex Technologies Inc., and Xenon Pharmaceuticals Inc. Isis Pharmaceuticals, Inc. was founded in 1989 and is headquartered in Carlsbad, California.

isis pharmaceuticals inc (ISIS) Top Compensated Officers

Founder, Executive Chairman, Chief Executive ...
Total Annual Compensation: $1.5M
Chief Financial Officer, Principal Accounting...
Total Annual Compensation: $581.4K
Chief Operating Officer, Corporate Secretary,...
Total Annual Compensation: $1.2M
Senior Vice President of Antisense Research
Total Annual Compensation: $631.6K
Senior Vice President of Development
Total Annual Compensation: $624.4K
Compensation as of Fiscal Year 2013.

isis pharmaceuticals inc (ISIS) Key Developments

First Infant Receives Their First Dose of ISIS-SMN in the Isis Pharmaceuticals, Inc

On August 21, 2014, the first infant received their first dose of ISIS-SMN in the Isis Pharmaceuticals, Inc. Phase 3 study, ENDEAR, which is evaluating ISIS-SMN in infants with spinal muscular atrophy (SMA). Isis earned an $18 million milestone payment from its development partner, Biogen Idec International Holding Ltd. as a result of Isis' achievement of this milestone event. The ENDEAR study, is the first Phase 3 clinical study for ISIS-SMN. Isis plans to initiate a second pivotal study in children with SMA later in 2014 and additional studies are in the planning stages.

ISIS Pharmaceuticals Inc. Announces Unaudited Consolidated Earnings Results for the Second Quarter and Six Months Ended June 30, 2014; Provides Revenue Guidance for the Full Year 2014

ISIS Pharmaceuticals Inc. announced unaudited consolidated earnings results for the second quarter and six months ended June 30, 2014. For the second quarter, the company reported total revenue was $57,076,000 compared with $38,092,000 for the same period in the last year. Loss from operations was $6,650,000 compared with $7,928,000 for the same period in the last year. Loss before income tax was $11,200,000 compared with $11,307,000 for the same period in the last year. Net loss was $12,081,000 compared with $10,126,000 for the same period in the last year. Diluted net loss per share was $0.10 compared with $0.09 for the same period in the last year. Pro forma operating profit was $1.1 million. For the six months, the company reported total revenue was $85,237,000 compared with $81,451,000 for the same period in the last year. Loss from operations was $121,554,000 compared with $87,755,000 for the same period in the last year. Loss before income tax was $44,756,000 compared with $13,042,000 for the same period in the last year. Net loss was $43,361,000 compared with $11,798,000 for the same period in the last year. Diluted net loss per share was $0.37 compared with $0.11 for the same period in the last year. The company provided revenue guidance for the full year 2014. For the period, the company's revenue, most significantly milestone payments, the company have earned more than $85 million so far this year and the company is on track to meet guidance of more than $150 million in total revenue for this year 2014.

Isis Pharmaceuticals Begins Phase III Endear Trial for Spinal Muscular Atrophy Treatment in Infants

Isis Pharmaceuticals has started a pivotal Phase III trial called Endear, evaluating ISIS-SMN in infants with spinal muscular atrophy (SMA), the most common genetic cause of infant mortality. The dosing of the first infant in this trial will be carried out within the next few weeks. At that time the company will earn an $18 million milestone payment from its development partner, Biogen Idec. Endear is the first of several planned trials in a broad and comprehensive late-stage clinical development programme for ISIS-SMN. The company is also planning to begin a second pivotal trial in children with SMA later in 2014. A total of 110 infants diagnosed with SMA will be participating in the randomised, double-blind, sham-procedure controlled thirteen month Phase III Endear trial. The trial will assess the efficacy and safety of a 12mg dose of ISIS-SMN with a primary endpoint of survival or permanent ventilation, with additional efficacy endpoints also included in the trial.

 

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