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As of 8:10 PM 08/29/14 All times are local (Market data is delayed by at least 15 minutes).

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islet sciences inc (ISLT) Details

Islet Sciences, Inc., a biotechnology company, is engaged in the research, development, and commercialization of new medicines and technologies for the treatment of metabolic diseases and related indications covering unmet medical needs. The company offers ISLT-P, an implantable suspension of encapsulated insulin-producing porcine islet cells for the treatment of insulin-dependent diabetes; ISLT-2669, a novel lead IL-12 small molecule inhibitor selected for preclinical development for treatment of type 2 diabetes; and ISLT-LSF Analogs, a library of small molecule lisofylline analogs that block inflammatory actions of cytokines, which destroy insulin-producing beta cells for diabetes and diabetes-related complications. It is also involved in developing ISLT-Bdx, a PCR based molecular diagnostic measuring hypomethylated beta cell-derived DNA as a biomarker of beta cell loss for the early detection of type 1 diabetes or onset of insulin dependent type 2 diabetes. In addition, the company develops Remogliflozin, a selective SGLT2 inhibitor in Phase II clinical development for type 2 diabetes and nonalcoholic steatohepatitis. Islet Sciences, Inc. was founded in 2010 and is based in Raleigh, North Carolina.

3 Employees
Last Reported Date: 07/28/14
Founded in 2010

islet sciences inc (ISLT) Top Compensated Officers

Chairman and Chief Executive Officer
Total Annual Compensation: $75.0K
Chief Operating Officer, Director and Chairma...
Total Annual Compensation: $75.0K
Compensation as of Fiscal Year 2014.

islet sciences inc (ISLT) Key Developments

Islet Sciences, Inc. Receives Notice of Allowance for U.S. Patent Covering Novel II-12 Inhibitors

Islet Sciences, Inc. announced that it has received a Notice of Allowance from the United States Patent and Trademark Office (USPTO) for its patent application titled, "Lisofylline Analogs and Methods for Use." The new patent (U.S #13/477,613) will extend coverage to include a significantly broader gamut of chemical compounds, which Islet may develop as immune-modulating drugs targeting an inflammatory pathway involved in a number important diseases, including diabetes and nonalcoholic steatohepatitis (NASH). Lisofylline (LSF) and its analogs have been shown to inhibit activation of pro-inflammatory immune signaling molecules IL-12 and STAT4, but clinical utility of these compounds has been limited by poor drug qualities. Islet Sciences is working to identify and develop first-in-class LSF analogs with superior chemical properties suitable for commercial drug development. Initial screens uncovered first-generation IL-12 antagonists able to protect insulin-producing beta-cells and preserve islet function in vitro, as well as delay onset of type I diabetes in a mouse model. Additional studies showed these immune modulators may directly reduce liver fibrosis in a rat model of NASH. The parent molecule, LSF, has also been examined in three human clinical studies where it was well tolerated with no serious adverse events. This patent allowance further strengthens dominant intellectual property position by broadening the scope of compounds can develop as IL-12 antagonists, and in effect, potentially broadening the types of diseases it may be able to address. In addition to diabetes and NASH, other studies suggest IL-12 inhibitors may be effective for atherosclerosis, diabetic nephropathy, and other diseases.

Islet Sciences, Inc. Auditor Raises 'Going Concern' Doubt

Islet Sciences, Inc. filed its 10-K on Jul 28, 2014 for the period ending Apr 30, 2014. In this report its auditor, Pannell Kerr Forster, gave an unqualified opinion expressing doubt that the company can continue as a going concern.

Islet Sciences, Inc. Announces Peer-Reviewed Publication of Study Validating Novel Diabetes Diagnostic

Islet Sciences, Inc. announced that its collaborators at the Yale University School of Medicine have published key data highlighting the efficacy of Islet's novel diabetes diagnostic in Endocrinology. The study demonstrated improved detection of beta-cell loss, a key biomarker of diabetes progression, using a novel technology called droplet digital PCR (ddPCR). In the peer-reviewed journal article, titled Analysis of beta-cell death in Type 1 diabetes by droplet digital PCR, the authors describe how this novel approach is the first to enable accurate quantification of the level of insulin (INS) DNA released into the blood specifically from dying beta-cells. This highly sensitive technique not only allowed researchers to distinguish patients with recent onset type 1 diabetes from non-diabetic control patients, but also for the first time provided evidence of ongoing beta-cell loss in non-diabetic patients who are at risk of developing disease based on family history and other factors. Therapies designed to prevent or reverse type 1 diabetes generally focus on preserving beta-cell function by preventing cell death or replacing lost beta-cells. However, by the time symptoms such as hyperglycemia begin, approximately 80% of the beta-cells have already been destroyed and it can often be too late for these treatments to be effective. An accurate method to detect beta-cell loss at an early stage, such as ddPCR, may permit medical intervention at a time when these therapies would have the great benefit. Furthermore, the study also suggests that ddPCR may hold even greater value in uncovering beta-cell loss in normoglycemic, 'at-risk' individuals, enabling potential treatment before symptoms appear.


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