Last $4.62 USD
Change Today +0.07 / 1.54%
Volume 7.7K
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As of 11:09 AM 12/29/14 All times are local (Market data is delayed by at least 15 minutes).

tetralogic pharmaceuticals c (TLOG) Snapshot

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tetralogic pharmaceuticals c (TLOG) Details

TetraLogic Pharmaceuticals Corporation operates as a clinical-stage biopharmaceutical company in the United States. The company focuses on discovering and developing novel small molecule therapeutics that mimic novel second mitochondrial activator of caspases to cause or enable abnormal cells, which are resistant to the body’s immune system to self-destruct. Its clinical-stage product candidate, Birinapant, is in Phase I and Phase II oncology clinical trials for multiple solid tumors and hematological malignancies. The company’s clinical and pre-clinical programs comprise an ongoing Phase I/II clinical trial of birinapant as a single agent in various blood cancers; a Phase I/II completed clinical trial of birinapant administered with irinotecan in colorectal cancer; and a Phase I/II clinical trial of birinapant administered with conatumumab in ovarian cancer, as well as an intention to start Phase I clinical trial in hepatitis B virus. It has collaboration with Amgen, Inc. for exploring the combination of birinapant administered with Amgen’s TRAIL receptor agonist antibody, conatumumab. The company was formerly known as Gentara Corporation and changed its name to TetraLogic Pharmaceuticals Corporation in January 2006. TetraLogic Pharmaceuticals Corporation was incorporated in 2001 and is headquartered in Malvern, Pennsylvania.

20 Employees
Last Reported Date: 03/19/14
Founded in 2001

tetralogic pharmaceuticals c (TLOG) Top Compensated Officers

Chief Executive Officer, President and Direct...
Total Annual Compensation: $175.6K
Chief Financial Officer, Principal Accounting...
Total Annual Compensation: $141.2K
Chief Operating Officer and Chief Medical Off...
Total Annual Compensation: $137.2K
Chief Scientific Officer
Total Annual Compensation: $315.2K
Compensation as of Fiscal Year 2013.

tetralogic pharmaceuticals c (TLOG) Key Developments

TetraLogic Pharmaceuticals Corporation Announces Initiation of Randomized Phase 2 Clinical Trial of Shape in Subjects with Cutaneous T-Cell Lymphoma

TetraLogic Pharmaceuticals Corporation announced the initiation of a randomized Phase 2 clinical trial of SHAPE in subjects with early stage cutaneous Tcell lymphoma. SHAPE has been evaluated in a randomized, dose escalation, placebo-controlled Phase 1 clinical trial in early-stage CTCL subjects that met safety endpoints and demonstrated clinical activity. Four of fifteen patients receiving SHAPE attained an objective response as measured by a greater than 50% improvement in their Composite Assessment of Index Lesion Severity, or CAILS, score during and after 28 days of dosing. No placebo patients responded. The randomized Phase 2 trial will be conducted in approximately sixty subjects with Stage IA-IIA CTCL. The objectives of the Phase 2 clinical trial are to evaluate the dose, clinical effect at 6 months (based on CAILS score), time to response, and tolerability of treatment of >2% body surface area.

TetraLogic Pharmaceuticals Corporation Provides Update on Ovarian Cancer Study

TetraLogic Pharmaceuticals Corporation announced that it intends to proceed with the expansion phase of its study in patients with ovarian cancer. The study is being conducted in patients who have failed up to three rounds of prior chemotherapy. In the study birinapant has been dosed twice weekly, 3 weeks out of 4, or 4 weeks out of 4, in combination with Amgen's TRAIL receptor 2 agonist antibody, conatumumab, dosed every 2 weeks. To date eighteen patients have been dosed in the Phase 1b portion of the study. Results thus far suggest a pharmacodynamic interaction between the two drugs, manifested as the appearance of adverse events at lower than anticipated doses. In addition, one patient showed a partial response and two patients have maintained stable disease, one through four cycles of treatment, and one through two. Three additional patients are on study awaiting scans.

TetraLogic Pharmaceuticals Corporation Presents at 26th Annual Piper Jaffray Healthcare Conference, Dec-03-2014 10:00 AM

TetraLogic Pharmaceuticals Corporation Presents at 26th Annual Piper Jaffray Healthcare Conference, Dec-03-2014 10:00 AM. Venue: The New York Palace Hotel, 455 Madison Ave, New York, NY 10022, United States. Speakers: C. Glenn Begley, Chief Scientific Officer.


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