Last €8.56 EUR
Change Today -0.03 / -0.35%
Volume 13.6K
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As of 9:58 AM 07/28/14 All times are local (Market data is delayed by at least 15 minutes).

transgene sa (TNG) Snapshot

Open
€8.60
Previous Close
€8.59
Day High
€8.72
Day Low
€8.55
52 Week High
03/19/14 - €13.71
52 Week Low
09/4/13 - €8.04
Market Cap
329.1M
Average Volume 10 Days
25.6K
EPS TTM
€-1.30
Shares Outstanding
38.4M
EX-Date
--
P/E TM
--
Dividend
--
Dividend Yield
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Current Stock Chart for TRANSGENE SA (TNG)

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transgene sa (TNG) Details

Transgene S.A., a biopharmaceutical company, engages in the research, design, development, and manufacture of therapeutic vaccines and immunotherapeutic products to treat cancers and chronic infectious diseases. Its principal products under Phase II clinical trials include TG4010 for the treatment of metastatic non-small cell lung cancer in combination with chemotherapy; Pexa-Vec primarily for the treatment for liver cancer; TG4001, a therapeutic vaccine for oropharyngeal cancer caused by an infection by the human papilloma virus (HPV); and TG4040 for the treatment of chronic hepatitis C. The company has agreements with Novartis for the development of TG4010 to treat various cancers; Jennerex Biotherapeutics, Inc. for the development and marketing of Pexa-Vec, an oncolytic product; and European Organization for Research and Treatment of Cancer for the development of TG4001 to treat HPV induced head and neck cancers. The company was founded in 1979 and is headquartered in Illkirch-Graffenstaden, France. Transgene S.A. is a subsidiary of TSGH SAS.

262 Employees
Last Reported Date: 04/17/14
Founded in 1979

transgene sa (TNG) Top Compensated Officers

Chairman and Chief Executive Officer
Total Annual Compensation: €72.2K
Compensation as of Fiscal Year 2013.

transgene sa (TNG) Key Developments

Transgene Announces Results in an Update from the Phase 2b Part of TIME Trial with TG4010 in Advanced Non-Small Cell Lung Cancer

Transgene SA announced promising results in an update incorporating more mature data from the Phase 2b part of the Phase 2b/3 TIME trial with TG4010 MUC-1 targeted immunotherapy in patients with advanced non-small cell lung cancer (NSCLC). Following an analysis conducted with a more mature dataset, the primary endpoint of progression-free survival (PFS) to validate the TrPAL predictive biomarker was met in the normal TrPAL group. The high TrPAL group had not yet met the required number of events to conduct the primary analysis. Importantly, in the subgroup of patients of non-squamous histology (191 out of 217 patients), the vast majority of patients in the trial, the difference in PFS was statistically significant and clinically meaningful with a p value of 0.02 and a stratified log rank hazard ratio (HR) of 0.71 [0.51; 0.98] (intent-to-treat analysis). As expected, in this non-squamous population, the PFS HR observed was even more notable in the normal TrPAL subgroup of patients. TG4010 was well tolerated, and the nature and incidence of adverse events in the TG4010 arm were consistent with previous Phase 2 clinical trials. To date, over 350 patients have been treated with TG4010. Data for overall survival, a secondary endpoint in the TIME trial, although not yet mature, are suggesting a clinically meaningful improvement in line with the one observed with the PFS data. Detailed results from the TIME trial, including overall survival, are expected to be presented at a major medical meeting later this year. The Company will be interacting with regulatory authorities to discuss the data from the TIME trial in preparation of the phase 3 part of the trial.

Transgene SA Presents at European Midcap Event "Spring", Jun-26-2014

Transgene SA Presents at European Midcap Event "Spring", Jun-26-2014 . Venue: Paris, France.

Transgene SA Provides an Update on TG6002

Transgene SA provided an update on TG6002, the company's proprietary oncolytic immunotherapy being developed for the treatment of solid tumors. TG6002 was discovered and designed by Transgene, which owns all development and commercialization rights to the program. TG6002 is currently in pre-clinical testing and has shown activity in several human tumor mouse models. The company currently plans to initiate human clinical testing in 2015. TG6002 (VV-TK-RR-FCU1) is a replicative and propagative viral vector (Vaccinia virus) expressing the FCU1 gene. Resulting from modifications of the viral vector, the propagation of TG6002 is restricted to the tumors, reducing toxicity to normal cells while inducing the breakdown of cancer cells, called oncolysis. The expression of the FCU1 gene in cancer cells infected by TG6002 enables the transformation of the non-cytotoxic pro-drug, flucytosine (5-FC), into 5-FU, a widely used chemotherapy. Thus, TG6002 combines oncolytic immunotherapy with localized and targeted chemotherapy. The mechanisms of action are different from standard therapies such as chemotherapy, tyrosine kinase inhibitors, antibodies and radiotherapy, and TG6002 holds the potential to be used in combination with such treatments. Pre-clinical testing of TG6002 is ongoing and includes toxicity testing, as well as evaluating combinations with other novel therapies such as immune checkpoint inhibitors. Upon conclusion of pre-clinical studies and regulatory submission, a Phase 1, first-in-humans dose-escalation study is expected to be initiated in patients with advanced solid tumors during 2015.

 

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TNG

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Valuation TNG Industry Range
Price/Earnings NM Not Meaningful
Price/Sales 17.0x
Price/Book 4.7x
Price/Cash Flow NM Not Meaningful
TEV/Sales 14.3x
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