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4sc ag (VSC) Details

4SC AG researches and develops small-molecule drugs for the treatment of cancer and autoimmune diseases. The company operates through two segments, Development and Discovery & Collaborative Business. Its product portfolio in the area of autoimmune includes Vidofludimus, an orally administered small-molecule drug, which is in Phase II b clinical trial for the treatment of crohn’s diseases. The company’s product portfolio in the area of oncology comprises Resminostat, an oral pan-histone-deacetylase inhibitor, which is in Phase II and Phase I clinical trials for the treatment of liver cancer, hodgkin lymphoma, colorectal cancer, non-small-cell lung cancer, and solid tumors; 4SC-202, an epigenetic anti-cancer compound that is in Phase I clinical trials for the treatment of hematologic tumors; and 4SC-205, an anti-cancer compound, which is in Phase I clinical trials for the treatment of solid tumors. It also conducts research programs in the areas of cancer immunotherapy, cancer stem cells, epigenetics, cytokine modulation, and ion channel blockers for the treatment of autoimmune, inflammatory eye, and oncology diseases. The company was founded in 1997 and is headquartered in Martinsried, Germany.

55 Employees
Last Reported Date: 11/7/14
Founded in 1997

4sc ag (VSC) Top Compensated Officers

Chairman of Management Board, Chief Executive...
Total Annual Compensation: €278.0K
Co-Founder, Chief Scientific Officer, Chief D...
Total Annual Compensation: €198.0K
Compensation as of Fiscal Year 2013.

4sc ag (VSC) Key Developments

4SC AG Reports Positive Topline Data from Clinical Phase I trial with 4SC-205 in Cancer Patients Using Novel Continuous Dosing Scheme

4SC AG announced positive top line data from the clinical Phase I AEGIS trial with the anti-cancer compound 4SC-205 in cancer patients. 4SC-205 inhibits specifically the human kinesin spindle protein Eg5 which has been shown to play a crucial role in cell division and, therefore, in tumour growth. To 4SC's knowledge, 4SC-205 is the only orally available Eg5 inhibitor in clinical development worldwide. Conducted at two trial centres in Germany, the open-label AEGIS dose-finding study for the first time investigated the innovative 4SC-205 compound in 59 patients with advanced solid tumours. This involved the testing of two separate dosing schemes. As previously reported, the first part of the study, treating 46 patients with 4SC-205 in a conventional dosing scheme (with single, larger doses and longer breaks between treatment days), had delivered promising initial results for pharmacokinetics, the tolerability profile and biomarkers. The second part of the study has been completed now. In this study amendment, 4SC-205 was evaluated in 13 patients with advanced solid tumours using a metronomic, or continuous, dosing scheme. In this regimen, patients received the compound, in smaller single doses, daily and continuously (= no breaks between treatment days). This regimen aims to achieve and maintain permanent therapeutically active levels of the drug in patients while keeping side effects tolerable at the same time. The oral availability of 4SC-205 and its mechanism of action as a potential cell division inhibitor make this dosing scheme promising from a scientific and clinical perspective. To the knowledge of the company, 4SC-205 is the first Eg5 inhibitor that has been clinically evaluated in patients in this dosing scheme to date. All primary objectives of the study amendment have been achieved. Alongside very good linear pharmacokinetic parameters, a comprehensive safety and tolerability profile was established for 4SC-205. The continuous daily dosage of 20 mg of the compound showed promising initial signs of efficacy and is recommended as the dosage regimen for potential Phase II development. Currently one patient whose previously strongly pronounced and highly aggressive cancer has been stabilized for eight months now is still continuing study treatment. 4SC will now proceed to discuss the results with external clinical key opinion leaders and potential partners, so as to assess further development options for 4SC-205 - such as a clinical Phase II trial. In the metronomic dosing scheme investigated in the study amendment, the patients were continuously treated (i.e. without breaks between treatment days) in three separate dosage groups that received daily doses of 10 mg, 20 mg or 30 mg of 4SC-205 respectively. The main study objective was to identify the maximum tolerated dose for the treatment and potential dose-limiting toxicities (DLTs). The main study phase to be completed by all patients according to the study protocol was six weeks, i.e. two continuous treatment cycles, each of 21 days. After completion of this main phase, the follow-up phase then allowed patients benefiting from the treatment - in the form of a stabilization of their previously progressive cancers - to continue the treatment. In these patients, the MTD was established as a daily dose of continuous 20 mg. The DLT was determined at a continuous daily dose of 30 mg of 4SC-205. Primary side effects at DLT level were neutropenia (level 3-4). Moreover, 4SC-205 showed a very good pharmacokinetic profile with a dose proportional increase of exposure and an elimination half-life of about ten hours providing the basis for effective dosing schedules. 4SC recommends the daily dose of 20 mg in the metronomic treatment regimen as a well tolerable and potentially effective dose (Recommended Phase 2 Dose, RP2D) for a possible Phase II development of the compound. Compared with the other doses examined in this trial, the six patients in this 20 mg daily metronomic group exhibited markedly superior indications for treatment efficacy, both in terms of a higher stabilization rate and a longer time on study. Accordingly, in a total of 50% of patients receiving this metronomic dose of 20 mg per day, the previously progressive cancer disease could be stabilized beyond the study's main phase into the follow-up phase. In comparison, the average stabilization rate of all patients was 30% in the metronomic dosing scheme and 20% in the conventional dosing scheme. The median time on study of the patients receiving the daily metronomic dose of 20 mg was 128 days. In comparison, the median time on study for all patients in the metronomic dosing scheme was 44 days and 40.5 days for all patients under the conventional dosing scheme. Currently one patient, whose previously strongly pronounced and highly aggressive cancer disease (malignant melanoma with pulmonary metastases) has been stabilized for eight months under the continuous daily dose of 20 mg 4SC-205, is still continuing study treatment.

4SC AG Presents at 4th Annual Berenberg 1 - 1 Symposium @ German Equity Forum, Nov-25-2014

4SC AG Presents at 4th Annual Berenberg 1 - 1 Symposium @ German Equity Forum, Nov-25-2014 . Venue: Maritim Hotel, Theodor-Heuss-Allee 3, 60486 Frankfurt am Main, Germany.

4SC AG Reports Consolidated Earnings Results for the Third Quarter and Nine Months Ended September 30, 2014; Provides Earnings Guidance for 2014

4SC AG reported consolidated earnings results for the third quarter and nine months ended September 30, 2014. For the first nine months of 2014, consolidated revenue increased by 66% year on year to EUR 6.18 million against EUR 3.72 million last year. This primarily comprises revenue generated under the cooperation agreements with BioNTech AG and LEO Pharma. Loss from operations improved by 25% to EUR 6.21 million in the reporting period against EUR 8.25 million last year, due to higher revenue. The loss for the period decreased by 23% to EUR 6.31 million against EUR 8.19 million last year, which corresponds to loss per share of EUR 0.12 against EUR 0.16 last year. This results in an average monthly outflow of cash from operations amounting to EUR 0.72 million in the first nine months of 2014 against EUR 0.59 million last year. For the quarter, consolidated revenue increased by 25% to EUR 2.20 million against EUR 1.77 million last year. Despite an increase in revenue, the company's loss from operating activities increased by 12% in the third quarter to EUR 2.34 million against EUR 2.08 million last year. This was due mainly to higher cost of sales in connection with the production of the resminostat compound for Yakult and higher development expenses in the context of optimizing the resminostat manufacturing process. Loss for the period increased by 11% to EUR 2.33 million in the third quarter against EUR 2.11 million last year, resulting in loss per share of EUR 0.05 against EUR 0.04 last year. On the revenue side, the incoming payments which the company originally assumed would be received by 4SC Discovery GmbH in 2014 are anticipated to be delayed until next year. For this reason, the company currently forecasts a cash burn rate for the coming year that is significantly lower than originally planned. For 2014, 4SC now expects an average monthly operating cash burn rate of between EUR 0.7 million and EUR 0.9 million. The 2014 operating loss at group level is likely to decrease further year on year.


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