Last $16.30 USD
Change Today +0.75 / 4.82%
Volume 442.0K
XNCR On Other Exchanges
Symbol
Exchange
NASDAQ GM
Munich
As of 5:20 PM 12/18/14 All times are local (Market data is delayed by at least 15 minutes).

xencor inc (XNCR) Snapshot

Open
$15.55
Previous Close
$15.55
Day High
$16.90
Day Low
$14.44
52 Week High
12/18/14 - $16.90
52 Week Low
01/22/14 - $7.77
Market Cap
511.7M
Average Volume 10 Days
147.2K
EPS TTM
--
Shares Outstanding
31.4M
EX-Date
--
P/E TM
--
Dividend
--
Dividend Yield
--
Current Stock Chart for XENCOR INC (XNCR)

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xencor inc (XNCR) Details

Xencor, Inc., a clinical-stage biopharmaceutical company, focuses on discovering and developing engineered monoclonal antibodies to treat severe and life-threatening diseases with unmet medical needs. It develops its antibody product candidates to treat autoimmune and allergic diseases, cancer, and other conditions through its proprietary XmAb technology platform. The company’s lead XmAb-engineered antibodies include XmAb5871, a B-cell inhibitor, which is in Phase Ib/IIa clinical trials for the treatment of autoimmune diseases, such as rheumatoid arthritis and lupus; XmAb7195, an IgE inhibitor under Phase Ib clinical trial initiation to treat asthma and allergic diseases; and XmAb5574/MOR208, a Cytotoxic B-cell depleting product candidate that is in Phase II clinical trials for the treatment of B-cell cancers. It has a collaboration agreement with Boehringer Ingelheim International GmbH; and development and manufacturing services agreement with Catalent Pharma Solutions LLC. The company was founded in 1997 and is based in Monrovia, California.

28 Employees
Last Reported Date: 03/31/14
Founded in 1997

xencor inc (XNCR) Top Compensated Officers

Co-Founder, Chief Executive Officer, Presiden...
Total Annual Compensation: $363.7K
Chief Medical Officer
Total Annual Compensation: $322.5K
Chief Business Officer
Total Annual Compensation: $290.0K
Compensation as of Fiscal Year 2013.

xencor inc (XNCR) Key Developments

MorphoSys AG and Xencor Inc. Publish Final Results from Phase 1/2a Trial of MOR208 (XmAb5574)

MorphoSys AG and Xencor Inc. announced the publication of final results of a Phase 1/2a trial evaluating MOR208 (formerly XmAb5574) in patients with relapsed or refractory chronic lymphocytic leukemia/small lymphocytic leukemia (CLL/SLL). MOR208 is a potent anti-CD19 antibody with a proprietary modification to the Fc portion that is being developed to treat B-cell malignancies. MOR208 was in-licensed by MorphoSys from Xencor in 2010. The results demonstrate that the drug was well tolerated and achieved durable responses in a high risk and poor prognosis patient population with significant progression-free survival achieved: At recommended dose 12 patients (75%) had a partial response by physical exam criteria (IWCLL1996) and 6 patients (37.5%) had a partial response using additional CT criteria (IWCLL2008); Blood disease cleared in most patients, with median reduction in absolute lymphocyte count from baseline of 90.8%; and progression-free survival of up to 60 weeks for patients in extended treatment arm. The Phase 1/2a trial was designed to assess the drug's safety, tolerability, pharmacokinetic profile and preliminary anti-tumor activity. MOR208 was administered as an intravenous infusion on days 1, 4, 8, 15, and 22 of cycle 1, and on days 1, 8, 15, and 22 of cycle 2. Dose levels tested ranged from 0.3 to 12 mg/kg with an expansion to a total of 16 patients at the high dose. In total, 27 patients were enrolled, with a median age of 66 years. The patients were generally high risk: 14 patients had high-risk disease by the Rai staging system; 18 patients had chromosome abnormalities -- 10 patients with del(17p13.1) and 8 with del(11q22.3); 24 patients had IgVH unmutated disease. All of these factors lead to a poor prognosis in clinical practice. Patients had a median of 4 prior therapies, with a range of 1 to up to 13. MOR208 was generally well tolerated with no maximum-tolerated dose identified. The most common adverse events were infusion reactions, increased aspartate transaminase (AST), increased alanine aminotransferase (ALT), neutropenia, thrombocytopenia, fever, chills, and peripheral neuropathy. Infusion reactions occurred in 67% of patients, however, all were grade 1 or 2, and no reactions were seen following the first infusion. On the basis of physical exam and laboratory studies, 18 patients (66.7%) achieved a partial response (PR), and the remaining 9 patients (33.3%) achieved stable disease (SD). Adding CT criteria, 8 patients (29.6%) achieved a PR with an additional 16 patients (59.3%) achieving SD. Two patients had progressive disease by CT criteria. Evaluating only the 16 patients at the 12 mg/kg dose level, which is the recommended phase 2 dose, 12 patients (75%) had a PR by physical exam criteria and 6 patients (37.5%) had a PR by CT criteria, two of these patients achieving the PR during the maintenance phase. Blood disease cleared in most patients, with a median reduction in absolute lymphocyte count from baseline of 90.8% and a decrease in CLL cell count. Median progression-free survival (PFS) for all patients was 199 days. For the 8 patients on the extended treatment cohort, PFS was 420 days.

Xencor, Inc. Presents at Oppenheimer 25th Annual Healthcare Conference, Dec-11-2014 11:30 AM

Xencor, Inc. Presents at Oppenheimer 25th Annual Healthcare Conference, Dec-11-2014 11:30 AM. Venue: The Crowne Plaza Hotel, New York, New York, United States. Speakers: Bassil I. Dahiyat, Co-Founder, Chief Executive Officer, President and Director.

Xencor, Inc. Announces Unaudited Earnings Results for the Third Quarter and Nine Months Ended September 30, 2014; Provides Capex Guidance for the Full Year of 2014, 2015 and 2016

Xencor, Inc. announced unaudited earnings results for the third quarter and nine months ended September 30, 2014. For the quarter, the company reported revenues of $848,000 compared with $3,162,000 for the same period a year ago. Loss from operations was $6,287,000 compared with $1,843,000 for the same period a year ago. Net loss attributable to common stockholders was $6,278,000 or $0.20 per diluted share compared with $4,184,000 or $57.87 per diluted share for the same period a year ago. The reduction in revenue for the three months ended September 30, 2014 compared to the same period in 2013 relates primarily to revenue earned under Xencor's Merck and CSL collaborations in 2013. The lower revenue earned in the nine months ended September 30, 2014 compared to the nine months ended September 30, 2013 is due to the Merck and CSL revenue earned in 2013 and $3.0 million in milestone revenue received under the Company's Morphosys collaboration in 2013. Revenues are earned from technology licensing fees and milestone payments from Xencor's partners for the license of its drug candidates and use of its proprietary XmAb antibody engineering technologies. For the nine months, the company reported revenues of $3,856,000 compared with $8,428,000 for the same period a year ago. Loss from operations was $15,107,000 compared with $6,810,000 for the same period a year ago. Net loss attributable to common stockholders was $15,073,000 or $0.48 per diluted share compared with net income attributable to common stockholders of $88,209,000 or $4.10 loss per diluted share for the same period a year ago. Based on current operating plans, Xencor expects to have sufficient cash to fund research and development programs and operations through 2016, and maintains the 2014 year-end cash and cash equivalents estimate of approximately $54 million.

 

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