Last $57.46 USD
Change Today -0.71 / -1.23%
Volume 294.0K
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As of 1:05 PM 04/23/14 All times are local (Market data is delayed by at least 15 minutes).
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Company Description

Contact Info

251 Ballardvale Street

Wilmington, MA 01887

United States

Phone: 781-222-6000


Charles River Laboratories International, Inc., together with its subsidiaries, provides research models and associated services, and outsourced preclinical services to accelerate the drug discovery and development process. Segments The company operates in two segments, Research Models and Services (RMS) and Preclinical Services (PCS). RMS The RMS segment supplies research models to the drug development industry. With approximately 150 different strains, the company produces and sells rodent research model strains, principally genetically and microbiologically defined purpose-bred rats and mice. The company also provides various related services that are designed to assist its clients in supporting the use of research models in drug discovery and development. The RMS segment comprises Research Models, Research Model Services, and Endotoxin and Microbial Detection. Research Models: The company’s Research Models business comprises production and sale of research models and avian vaccine services. A portion of this business includes the commercial production and sale of research models, principally purpose-bred rats and mice for use by researchers. The company provides its rodent models to various clients worldwide, including various pharmaceutical companies, a range of biotechnology companies, government agencies, and hospitals and academic institutions. The company’s research models include both standard strains and disease models, such as those with compromised immune systems, which are in demand as early-stage research tools. The company’s small research models include outbred, which are purposefully bred for heterogeneity; inbred, which are genetically identical; hybrid, which are the offspring of two different inbred parents; spontaneous mutant, which contain a naturally occurring genetic mutation (such as immune deficiency); and other genetically modified research models, including knock-out models with one or more disabled genes and transgenic models. The company also offers proprietary, disease-specific mouse and rat models used to find new treatments for diseases, such as diabetes, obesity, cardiovascular, and kidney disease. The company focuses its disease model program on five areas of research: oncology, central nervous system, metabolic, cardiovascular and renal diseases. The company supplies SPF fertile chicken eggs and chickens. SPF chicken embryos are used by animal health companies as self-contained ‘bioreactors’ for the manufacture of live viruses. The company has a worldwide presence, with SPF egg production facilities in the United States, contracted production capabilities in Hungary, and franchise operations in India. The company also operates a specialized avian laboratory in the United States, which provides in-house quality control testing of the SPF flocks, offers testing services to vaccine companies and commercial poultry operations, and manufactures poultry diagnostics and bulk antigens for poultry vaccines. Research Model Services: RMS also offers various services designed to support its clients' use of research models in screening drug candidates. These services capitalize on the technologies and relationships developed through its research model business, and address the need among pharmaceutical and biotechnology companies to outsource the non-core aspects of their drug discovery activities. These services include those which are related to the maintenance and monitoring of research models, and those which are designed to implement efficacy screening protocols to improve the client's drug evaluation process. The company offers four major categories of research models services, such as Genetically Engineered Models and Services, Insourcing Solutions, Discovery Research Services and Research Animal Diagnostic Services. Genetically Engineered Models and Services (GEMS): The company breeds and maintains research models purchased or purposefully created by its clients for biomedical research activities. The company also provides breeding expertise and colony development, quarantine, health and genetic monitoring, germplasm cryopreservation, and rederivation, includi


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