TopSpin Medical, Inc., through its subsidiary, Metamorefix Ltd. (Metamorefix), engages in the examination, research, and development of technologies that facilitate the healing, rejuvenation, and repair of tissues, such as skin tissues that have sustained damage from injuries, wounds, or due to aging. The technologies developed by Metamorefix are based on an integration of developed products into the body’s natural and spontaneous healing processes. The first technology developed by Metamorefix is based on a combination of hyaluronic acid and fibrin. Hyaluronic acid is a polymer that is found in various human tissues (such as skin and cartilage). It is known as a substance that promotes healing processes. Fibrin is a protein that is created naturally in the body after sustaining skin tissue damage (also known as ‘blood clotting’), Metamorefix developed controlled processes that allow for the formation of fibrin based on a combination of thrombin and fibrinogen, as a stable, functional powder, which serves as an optimal environment for cell growth. Metamorefix has chosen two fields for the implementation of the technology, such as aesthetics (the filling and treatment of wrinkles) and the healing of wounds. The product developed by Metamorefix is a natural tissue healing and dermal filler substance, which the company refers to as the Dermal Filler. The Dermal Filler contains hyaluronic acid combined with the fibrin powder. Suppliers The company’s suppliers include BioTechnology General (BTG) Israel, a company owned by Ferring Pharmaceuticals and Novozymes A/S. Regulations Metamorefix’s activities are subject to compliance with various local and international standards and the regulation of various authorities, including the United States Food & Drugs Administration; and the Israeli Ministry of Health. Research and Development As of December 31, 2011, the company invested a total of New Israeli Shekel 7,890,000 (approximately $2,064,904) in gross research and development expenses. Intellectual Property As of December 31, 2011, the company’s subsidiary, TopSpin Medical (Israel) Ltd., owned one registered patents in the United States. Competition The company’s major competitors include Kinetic Concepts (KCI); Smith & Nephew; ConvaTec; Molnlycke Health Care; Systagenix Wound Management; and Coloplast. History TopSpin Medical, Inc. was founded in 2007.
knowledgetree ventures inc
16 Hatidhar Street
PO Box 4131
Phone: 972 9 744 2440
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